Sample Genetic Report

Your genetic profile shows a moderate polygenic risk for type 2 diabetes, placing you around the 67th percentile of the population. This means your combined genetic variants contribute somewhat more to diabetes risk than average, but it's far from deterministic. The most notable variant is rs7903146 in the TCF7L2 gene, where you carry one copy of the risk allele T. This is one of the strongest known genetic risk factors for type 2 diabetes, associated with a 37% higher relative risk per copy. TCF7L2 plays a key role in insulin secretion from pancreatic beta cells. You also carry two copies of the risk allele at rs5219 in KCNJ11, a potassium channel gene involved in glucose-stimulated insulin release. It's important to note that these are population-level statistical associations. Your actual risk depends heavily on lifestyle factors — diet, exercise, weight management, and family history matter enormously. Many people with higher genetic risk never develop diabetes, and vice versa. With 42 of 78 known variants analysed (54% coverage), these results give a reasonable but incomplete picture. This is not a diagnosis and should not replace medical advice.

Your genetic profile shows elevated risk for Alzheimer's disease, primarily driven by the APOE gene variant rs429358. You carry one copy of the APOE-e4 allele, which is the single strongest common genetic risk factor for late-onset Alzheimer's. Each copy is associated with roughly 3.7 times the risk compared to the common APOE-e3 variant — this is a substantial effect by genetic standards. However, carrying one APOE-e4 copy does not mean you will develop Alzheimer's. Many carriers live into old age without cognitive decline, and many non-carriers do develop it. Emerging research suggests that cardiovascular health, physical activity, cognitive engagement, and sleep quality all influence whether genetic risk translates into disease. With only 8 of 15 known variants analysed (53% coverage) and medium confidence, this estimate is informative but not comprehensive. This is a statistical association, not a clinical prediction, and should be discussed with a healthcare professional.